Here's the stuff I would have picked:
Best Studio: Bungie
Best Action Adventure Game: Assassin's Creed: Brotherhood
Best Shooter: Halo: Reach
Best RPG: Mass Effect 2 (Fallout: NV was *this* close)
Best Independent Game: Limbo
Best Downloadable Game: Monday Night Combat
Best DLC: Lair of the Shadow Broker
Best Score: Halo: Reach
Best Performance by a Male: Rob Wiethoff (Jon Marston, Red Dead Redemption)
Best Performance by a Female: Yvonne Strahovski (Miranda Lawson, Mass Effect 2)
Character of the Year: Ezio if I'm confined to their nominees, Illusive Man if I'm not
Game of the Year: Red Dead Redemption
Couple of things struck me as odd: how does Mario Galaxy 2 make it into the Action Adventure category? And how does Buck get the nomination for Best Performance? He was in Reach for like 10 seconds.