The Legend of Zelda: Breath of the Wild
BotW was obviously a great game, but even beyond that, it really encapsulated a lot of the changes gaming went through this decade, and it managed to do it without losing the magic of the series (*cough*Assassin's Creed*cough*). It took a series that had been largely the same formula since Ocarina of Time*, smashed it to bits, and rebuilt it from the ground up, while still feeling like a continuation of what came before. Where previous Zeldas were divided into the overworld and dungeons, with progress gated by specific items, and puzzles that cannot be completed without them, BotW goes full open-world, with system-driven gameplay. I don't know of anything more 2010's than open-world, system-driven. You get every ability/item within the first couple hours of the game, and if you want you can completely ignore everything and run straight to the final boss (not that it's easy, but it's possible). On the flip-side of that, the game is very good at sign-posting where to go next, without railroading you into it. My problem with lots of open-world games is that they're too open, they feel too aimless, and I lose interest without a clear mid-term goal. BotW always has that mid-term goal, which allows you to screw around to your heart's content, but then as soon as you get tired of it and want to progress the narrative it's fairly clear where to go next. And it accomplishes this without cluttering the map with icons. The only icons on your map are the one quest marker (which you can determine which quest is tracked, or turn off completely) and ones you place there yourself. This means you don't just play the minimap, you actually look at the world and figure things out from there, which sounds like it could get frustrating, but the world is so well designed that you rarely lose your direction if you want to find it.
The Hyrule of BotW feels huge, and open, and empty, without being desolate. It's post-apocalyptic, but it's a green post-apocalypse. There are a just few small settlements, that truly feel like remnants of a collapsed civilization, clinging to life in the wilderness. The emptiness makes it the most real-seeming "wasteland" I've yet played in. It's not Rapture, where the lore says there's a semi-functioning society still, but the world looks completely destroyed with only crazed psychopaths in sight. Nor is it the densely-populated wasteland of Fallout, which has too much civilization for how disorganized the lore says it is, but simultaneously too many hordes of bandits and monsters right next to the settlements. Each village in BotW feels isolated from the rest, but also like it could be reasonably self-sufficient, and the monster camps are close enough to be threatening without being so close as to make you wonder how the town is still around at all. And on a more minor note, the towns feel like actual towns, unlike the "towns" in Fallout that consist of two houses and five people, with one quarter-acre farm.
In short, Breath of the Wild exemplifies the trends of the decade, while also doing them better than any other game I've played.
Honorable Mention:
Prey, for similar reasons to Zelda. Talos has all the charm of Rapture, without the ludo-narrative dissonance of there supposedly being a functioning society still around somewhere, and the systems-based approach to problem solving is a joy.