Played Sentinels of the Multiverse for the first time with four friends. That was a lot of fun. It takes a little getting used to all the little things that come into play (damage dealt +1 for certain villains, environment damages everything at the end of a go, etc.), but it feels like a well-balanced RPG boss. My friends are all MMO veterans, so they grasped the tactical nature of things early on, and it's quite easy get a handle on each hero's strengths fairly quickly. Also had an app that was handy for tracking the villain's HP without switching around hit-point counters or anything like that.
Did one game against a low difficulty boss, who got some killer cards early on, but was a cinch after that. Then we went against the highest difficulty boss in this pack, who again started strong due to their deck, but my character steadily became very useful (along with some proper teamwork and consultation) so I was a big damage-dealer and a decent support character. We did lose one hero during the game but that's because they were taking a risk whereby they could deal damage equal to the difference between their max HP and their current HP (which would've been a massive blow to the villain) but got delayed when another card made the villain immune and then unlucky with a bit of damage just before their go.
Either way, if you like card games, superheroes and local co-op stuff, I highly recommend this.