They're going to play as close as possible to a 360 pad/ Dualshock as the Wii U can deliver. That's the dominant control scheme. Given that fair chunk of muli-plats don't tend to map to the creative applications of kb/m well I can't see them putting too much effort into them making much use of the screen. And if the Wii U ends up with the same userbase as the Wii the M rated 3rd parties will dry up pretty fast.
Nintendo haven't been too up front on any tech specifics, but it's guestimated to be around SD. It's a 6 inch screen, it would be quite expensive and pointless to be putting in a HD display.
This is the Wii U after all and I'd wager the apple won't fall far from the tree. If it's easy to port then you'll see some multi-plats running on it. But once the new consoles from MS n Sony hit the 3rd parties won't care much for it, and it'll be back to COD: Reflex and other spin-offs made by outsourced studios. It'll only be rubbing shoulders in terms of power for about 2 years.
Also the appeal of the console drops a fair bit when they show off this new controller, and ultimately most of your game time with the console is going to be with your old wiimotes like your old Wii. Considering the fact that it's most likely the controller that's going to make it expensive (as they've warned of) it's a bit of a sour point that the major cost of the console is going to be something you can't much use. It would be like if even the base 360 came with Kinect regardless and it only properly supports like 30 games. (kinect on top pushes 360 from £140 to £245, quite a bump)
Been able to do two slightly ups it's chances, though that would be something to have maybe been sure of when they came to E3 instead of being a bit unsure even among the heads of Nintendo. (Though this news is through Pachter, and everyone else seemed pretty adamant it would only support one and they'd never sell extras in store so maybe some extra confirmation needed on that)