Soul Calibur IV
Played SCII to death on the GameCube. The absence of Link and being forced to play with a PS3 controller might have had something to do with it.
Red Dead Redemption
Not a terrible game, but the trailers got me way too hyped for what was essentially GTA4 with horses.
Prototype
I thought it looked very bland and uninteresting, but it was much worse than that.
Final Fantasy XIII
The world felt too lifeless and restricted, and the characters annoyed me too much.