Just finished my first legacy game of Pandemic Legacy!
We ended up losing, and now Chicago, Montreal, and New York are in riots, with Atlanta, Washington, Tokyo, Seoul, and Buenos Aires unstable. At the end of the game we got to choose two upgrades, so we added a new starting research center and have the scientist the ability to hold an extra card in their hand.
It seriously stresses my wife out that permanent changes have been made to the game, but I love it. I'm excited to try January again.